The ACLU of Indiana is overseen by a Board of Directors that consists of 12 regional directors, nine at-large directors and nine board-appointed directors. The Board of Directors meets at least three times a year to set policy, appoint the executive director as needed, acquire and dispose of property, and engage in other activities consistent with the mission of the organization. Directors serve three-year terms. Members of the Board of Directors receive no compensation for their services.

Current members of the Board of Directors include:
Caroline Richardson, President, Indianapolis
Tamara Winfrey-Harris, Vice-President, Indianapolis
Kevin McElmurry, Secretary, Gary
Cris Halter, Treasurer, Indianapolis
Georgia Cravey, Equity Officer, Indianapolis
Andrea Cohen, Indianapolis
Emma Crossen, Terre Haute
Robert Dion, Evansville
Luis Fuentes-Rohwer, Bloomington

Michael Grossberg, Bloomington
Greg Hasty, Fishers
Larry Hesson, Plainfield
Sara Hindi, Indianapolis
Terri R. Jett, Indianapolis

Dorie Hertzel Maryan, Mooresville
Han Jacobs Meadway, Indianapolis
Mark Nicholson, Indianapolis

Nancy Papas, Indianapolis
Roberta Schonemann, West Lafayette
David Shircliff, Bedford

Fran Watson, Indianapolis
Reba Boyd Wooden, Greenwood