The ACLU of Indiana is overseen by a Board of Directors that consists of 12 regional directors, nine at-large directors and nine board-appointed directors. The Board of Directors meets at least three times a year to set policy, appoint the executive director as needed, acquire and dispose of property, and engage in other activities consistent with the mission of the organization. Directors serve three-year terms. Members of the Board of Directors receive no compensation for their services.

Current members of the Board of Directors include:
Tamara Winfrey-Harris, President, Indianapolis
Robert Dion, Secretary, Evansville
Emma Crossen, Treasurer, Terre Haute
Sara Hindi, AEO Officer, Carmel
Geraldine Chavez Mahoney, Mishawaka

Emma Crossen, Terre Haute
Anthony Fargo, Bloomington
Luis Fuentes-Rohwer, Bloomington

Kyle Grubbs, North Manchester
Christopher Hegerty, Lafayette
Cris Halter, Indianapolis
William Harrington, Avon

Greg Hasty, Fishers
Mark Nicholson, Indianapolis
Caroline Richardson, Indianapolis

David Shircliff, Bedford
Ellen Wu, Bloomington